Symbol
Name
ID

Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
MGI:1354953

Phenotype annotations related to renal/urinary system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Proteinuria	Minimal change glomerulonephritis	Steroid-resistant nephrotic syndrome	Stage 5 chronic kidney disease
Disease(s) Associated with MAGI2
nephrotic syndrome type 15

Mouse Phenotypes

absent glomerular endothelium fenestra

increased urine protein level

albuminuria

tubulointerstitial nephritis

abnormal glomerular capsule parietal layer morphology

abnormal podocyte morphology

abnormal podocyte foot process morphology

fused podocyte foot processes

podocyte foot process effacement

abnormal podocyte slit diaphragm morphology

absent podocytes

podocyte hypertrophy

podocyte microvillus transformation

expanded mesangial matrix

cortical renal glomerulopathies

glomerulosclerosis

glomerular crescent

renal interstitial fibrosis

renal tubule atrophy

renal cast

abnormal glomerular filtration barrier function

kidney failure

anuria

Availability

Mouse Genotype

Magi2^tm1.1Knis/Magi2^tm1.1Knis

Magi2^tm1Key/Magi2^tm1Key

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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